Narcotic treatment of anal fissure pain

To treat anal fissure, internal anal sphincterotomy may be associated with surgical risks and incidence of incontinence. Botulinum toxin injection into the anal sphincter is invasive and expensive. Headache and hypotension hindered topical treatment with glyceryl trinitrate. Greater patient compliance, potentiated efficacy, reduced side effects, and lower cost are the major advantages offered by the combination therapy. Therefore, combination topical gels of nifedipine NIF , lidocaine hydrochloride LDH and betamethasone valerate BMV were prepared and evaluated regarding viscosity, pH, drug content, and in vitro release. Compatibility study of drug—drug and drug-excipient mixtures preceded the formulation.
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04.03.2021
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Anal fissure

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Potential combination topical therapy of anal fissure: development, evaluation, and clinical study†

You are viewing BNF. An anal fissure is a tear or ulcer in the lining of the anal canal, immediately within the anal margin. Clinical features of anal fissure include bleeding and persistent pain on defecation, and a linear split in the anal mucosa. Initial management of acute anal fissures present for less than 6 weeks should focus on ensuring that stools are soft and easily passed.
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Potential combination topical therapy of anal fissure: development, evaluation, and clinical study†

This is a single institution nonexperimental study intended to analyze the therapeutic efficacy of topical diazepam in treating symptoms of chronic anal fissures. Anal fissures are a common cause of anal pain. Conventional treatments include nonsteroidal anti-inflammatory drugs, topical creams, such as nitroglycerin and nifedipine, and surgery.
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This page has been produced in consultation with and approved by:. Anyone of any age can be struck by appendicitis, but it seems to be more common during childhood and adolescence. Barium tests are used to examine conditions of the digestive tract such as reflux, narrowing or ulceration.
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